By Keith Suter
Talking at once approximately one of many gravest subject matters in contemporary political background, this authoritative consultant offers a concise review of the heritage and politics of terrorism. Conflicts from worldwide are tested intimately, together with terrorist efforts within the heart East, Russia, Northern eire, Indonesia, and Sri Lanka. Wider themes also are mentioned, together with easy methods to take care of rogue states to the effectiveness of present intelligence companies.
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Extra info for All About Terrorism: Everything You Were Too Afraid to Ask
Development of new vaccines is limited by the paucity of information about the virulence determinants of Ft. This project will provide (1) measures to extend the disease-free interval until definitive therapy/vaccines are implemented; and (2) vaccines that induce humoral and cellular immunity to Ft. Project 1A will characterize mechanisms by which the unusual Ft LPS induces mediators responsible for the systemic inflammatory responses of tularemia, and determine if reagents already under clinical testing for sepsis are useful in the treatment of disseminated tularemia in a murine model.
We will extend these studies to the hamster tracheal organ culture system developed by our laboratory and use these to study Y. pestis wild type organisms, as well as mutants of Yersinia lacking one or more of the three virulence plasmids. These studies will tell us more about how Yersinia interacts with host respiratory cells, and may provide new targets for therapeutics and plague vaccines. Generate_Screen • Project Title: EBOLA VP35 MEDIATED VIRAL MECHANISMS Principal Investigator & Institution: He, Bin; Microbiology and Immunology; University of Illinois at Chicago 1737 West Polk Street Chicago, Il 60612 Timing: Fiscal Year 2003; Project Start 01-AUG-2003; Project End 31-JUL-2005 Summary: (provided by applicant): Ebola virus is a highly dangerous pathogen causing hemorrhagic fever in humans.
As a potential gapfilling approach for the rapid development of safe and efficacious antiviral therapies for these agents, we propose to identify, isolate and characterize neutralizing human monoclonal antibodies (nhMAbs) reactive to the native forms of the envelope glycoproteins (Envs) of these viruses. The development of these nhMAbs would provide a valuable battery of post-exposure or post-infection therapeutics to combat disease Studies 29 caused by these agents. The antibodies will be obtained by screening human phage display libraries against the viral Envs.
All About Terrorism: Everything You Were Too Afraid to Ask by Keith Suter